Naproxen Liquid Gel Capsules - Uses, Side Effects, Interactions - (2023)

How does this medication work? What will it do for me?

Naproxen/naproxen sodium belongs to a group of medications callednonsteroidal anti-inflammatory drugs(NSAIDs). It reduces swelling, fever, inflammation and pain, and is used for therelief of mild to moderate pain accompanied by inflammation.

Naproxen/naproxen sodium is used to help relieve pain due to arthritis, muscle injury, (e.g., bone, muscle, tendon, cartilage, ligament), back pain, dental extraction, migraines, menstrual cramps, and pain after minor surgery. It is believed to work by stopping the production of prostaglandins, which cause pain and swelling.

This medication may be available under multiple brand names and/or in several different forms.Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles.If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor.Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do.It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Each clear, orange, oval, gelatin shell printed with “NX” in white ink and containing a clear, colourless-to-light-orange solution contains a total of 200 mg of naproxen as naproxen and naproxen sodium. Nonmedicinal ingredients: FD&C Yellow No. 6, gelatin, glycerin, polyethylene glycol, propylene glycol, povidone, sorbitan, sorbitol, and water.

How should I use this medication?

The recommended dose of naproxen/naproxen sodium for people 12 to 65 years of age is 200 mg taken by mouth every 8 to 12 hours. People over 65 years of age should take 200 mg by mouth every 12 hours. No more than 400 mg (2 doses) should be taken in any 24-hour period.

Naproxen/naproxen sodium may be taken with food or on an empty stomach, although it may take longer to notice an effect if it is taken with food or antacids.

When taken for fever, naproxen/naproxen sodium should not be used for more than 3 days. If used for pain, the medication should not be taken longer than 5 days. Contact your doctor after this time if you are still experiencing pain or fever.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications.If your doctor has recommended a dose different from the ones listed here,do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as recommended by your doctor or pharmacist.

Store this medication at room temperature, protect it from light, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take this medication if you:

  • are allergic to naproxen, naproxen sodium, or any ingredients of this medication
  • are allergic to ASA or other NSAIDs (e.g., ibuprofen, ketorolac, diclofenac) or have had allergic symptoms (e.g., runny nose, asthma, itchy skin rash, nasal polyps, swelling of the face, throat, or tongue) caused by these medications
  • are in your third trimester (last 3 months) of pregnancy
  • have an active or bleeding ulcer in the stomach or intestines
  • have inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease)
  • have severely reduced liver function or liver disease
  • have severely reduced or worsening kidney function

What side effects are possible with this medication?

Many medications can cause side effects.A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication.If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • diarrhea
  • dizziness
  • drowsiness
  • constipation
  • heartburn
  • indigestion
  • nausea
  • vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • confusion
  • decreased hearing, any other change in hearing, or ringing or buzzing in the ears
  • vision changes
  • swelling of the feet or ankles

Stop taking the medication and seek immediate medical attention ifanyof the following occur:

  • signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
  • symptoms of a severe allergic reaction, e.g.:
    • hives
    • shortness of breath
    • swelling of the face, mouth, throat, or tongue
    • trouble breathing or chest tightness
    • wheezing

Some people may experience side effects other than those listed.Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.


June 8, 2021

Health Canada has issued new information concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs). To read the full Health Canada Advisory, visit Health Canada's web site at

Allergic reactions:If you have had a reaction to acetylsalicylic acid (ASA) or other NSAIDs (e.g., ibuprofen, ketoprofen, ketorolac) that included a runny nose, itchy skin rash, nasal polyps, or shortness of breath and wheezing, you should not take this medication. If you experience symptoms of a severe allergic reaction (e.g., hives; difficulty breathing; wheezing; or swelling of the face, tongue, or throat), get immediate medical attention.

Blood clotting:This medication may reduce the ability of the blood to clot. If you are taking anticoagulants (e.g., warfarin, heparin) or have hemophilia or other blood disorders (e.g., low platelets), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you have a bleeding disorder, do not take this medication.

Blood pressure: This medication can cause fluid to build up in the body, increasing the amount of effort it takes for the heart to pump blood through the body. As a result, blood pressure can increase when taking naproxen/naproxen sodium. If you have high blood pressure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Drowsiness/reduced alertness:As with other NSAIDs, naproxen sodium can cause drowsiness, dizziness, and blurred vision. Avoid driving and other activities that require alertness and concentration until you determine the effect this medication has on you.

Heart function: This medication can cause fluid to build up in the body. This may decrease the effectiveness of the heart and contribute to heart failure. If you have heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Heart attack and stroke:This medication may be associated with an increased risk of heart attack and stroke. The risk is increased with higher total daily doses and taking the medication over long periods of time. If you have a history of heart disease (e.g., heart attack, stroke, heart failure) or have risk factors for heart disease (e.g., high blood pressure, high cholesterol, diabetes, smoking, kidney disease), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Skin reactions:This medication can cause skin reactions, some of which may be severe. If you experience a skin rash, especially where the skin is blistering or peeling, stop taking this medication and contact your doctor.

This medication may make your skin more sensitive to sunlight (including sunlamps) and may cause sunburn, skin blisters, and skin redness, itching, or discoloration. If you have a reaction from the sun while taking this medication, contact your doctor.

Ulcers or bleeding in the stomach or intestines:This medication can cause stomach ulcers, perforation (holes), and bleeding from the stomach, or can make these conditions worse.

The risk of ulcers and bleeding is increased if you are taking higher doses of this medication for longer periods of time.

If you currently have bleeding ulcers in the stomach or intestines, or have an inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis), you should not take this medication. If you have a history of these conditions, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Stop taking the medication and get immediate medical attention if you experience symptoms or signs of stomach ulcers or bleeding in the stomach (black and tarry stools, vomit that looks like coffee grounds, stomach pain). These reactions can occur without warning at any time during treatment.

Pregnancy:This medication should not be used during the third trimester (last 3 months) of pregnancy. This medication should not be used during the first and second trimester (first 6 months) of pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

This medication may reduce your ability to become pregnant. Taking this medication while trying to become pregnant is not recommended.

Breast-feeding:This medication passes into breast milk. If you are a breast-feeding mother and are taking naproxen/naproxen sodium, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children:The safety and effectiveness of using this medication have not been established for children less than 12 years of age.

Seniors:If you are a senior, you may have a higher risk of experiencing side effects from this medication. You should use the lowest effective dose under close medical supervision.

What other drugs could interact with this medication?

There may be an interaction between naproxen - naproxen sodium and any of the following:

  • 5-ASA medications (e.g., mesalamine, olsalazine, sulfasalazine)
  • acetylsalicylic acid (ASA)
  • alcohol
  • aliskiren
  • angiotensin converting enzyme (ACE) inhibitors (e.g., ramipril, enalapril)
  • angiotensin receptor blockers (e.g., valsartan, candesartan, losartan)
  • antacids
  • apixaban
  • beta blockers (e.g., metoprolol, atenolol)
  • bisphosphonates (e.g., alendronate, etidronate)
  • celecoxib
  • cholestyramine
  • clopidogrel
  • colestipol
  • corticosteroids (e.g., dexamethasone, prednisone)
  • dabigatran
  • dasatinib
  • deferasirox
  • deoxycholic acid
  • desmopressin
  • dipyridamole
  • cyclosporine
  • digoxin
  • diuretics (water pills; e.g., spironolactone, triamterene, furosemide, hydrochlorothiazide)
  • drospirenone
  • edoxaban
  • eplerenone
  • haloperidol
  • heparin
  • herbal products that affect blood clotting (e.g., cat's claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, turmeric)
  • hydralazine
  • ibrutinib
  • lithium
  • low-molecular-weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)
  • medications to break down blood clots (e.g., alteplase, defibrotide, streptokinase, urokinase)
  • methotrexate
  • multiple vitamin supplements with minerals
  • other non-steroidal anti-inflammatory drugs (NSAIDs e.g., diclofenac, ibuprofen, ketorolac)
  • obinutuzumab
  • omega-3 fatty acids
  • pemetrexed
  • pentoxifylline
  • porfimer
  • prasugrel
  • prostaglandin eye drops (e.g., latanoprost, bimatoprost)
  • quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
  • rivaroxaban
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
  • serotonin-norepinephrine reuptake inhibitors (SNRIs; desvenlafaxine, duloxetine, venlafaxine)
  • sodium phosphates
  • tacrolimus
  • tenofovir
  • ticagrelor
  • ticlopidine
  • tipranavir
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • vitamin E
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist.Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them.Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication.Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2022. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source:


Does naproxen have any drug interactions? ›

Naproxen interacts with medications that affect your kidneys, GI tract, or platelets. Common examples include aspirin, blood thinners, and methotrexate. Sometimes age and other health conditions make these interactions more likely to happen.

What is a potential serious side effect of naproxen? ›

Serious side effects

severe indigestion, heartburn, pains in your stomach, feeling or being sick (nausea or vomiting) or diarrhoea – these can be signs of an ulcer or swelling (inflammation) in your stomach or gut.

What are the most common side effects of naproxen? ›

The most common side effects of naproxen are confusion, headache, ringing in the ears, changes in vision, tiredness, drowsiness, dizziness and rashes. For strains and sprains, some doctors recommend waiting 48 hours before taking naproxen because it may slow down healing. If you're unsure, speak to a doctor.

What medicines Cannot be taken with naproxen? ›

Do not take naproxen with ibuprofen or other non-steroidal anti-inflammatory drugs (NSAIDs). But it's OK to take naproxen with paracetamol or co-codamol that you buy over the counter. This should just be for short periods of time.

Does naproxen interact with blood pressure meds? ›

Do not use naproxen sodium if you have high blood pressure, unless your doctor has said that it's safe. Naproxen sodium can also impair the effectiveness of common blood pressure medicines like ace inhibitors (such as Lotensin, Capoten, and Vasotec) and beta blockers (such as Coreg, Lopressor, and Corgard.)

What organs can naproxen affect? ›

Naproxen is a popular over-the-counter nonsteroidal antiinflammatory drug (NSAID) that is widely used for therapy of mild-to-moderate pain and arthritis. Naproxen has been associated with rare cases of clinically apparent drug induced liver injury.

Who should avoid taking naproxen? ›

You should not use naproxen if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID. Ask a doctor before giving naproxen to a child younger than 12 years old. If you are pregnant, you should not take naproxen unless your doctor tells you to.

Why can't you lay down after taking naproxen? ›

Doing so can release the drug too quickly, increasing the risk of side effects. Take this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug.

Does naproxen affect sleep? ›

Although drowsiness is an intended effect of naproxen sodium - diphenhydramine, it may cause morning sleepiness if it is taken too late at night. Alcohol and other medications that cause drowsiness may increase this effect.

Does naproxen raise blood pressure? ›

All nonsteroidal antiinflammatory drugs (NSAIDs) in doses adequate to reduce inflammation and pain can increase blood pressure in both normotensive and hypertensive individuals [1].

How long can you take naproxen safely? ›

People should only use OTC naproxen for a short-term period of between 3–5 days for pain and no more than 3 days for fever. If they need ongoing treatment, people should consult their doctor first. For children between 2–12 years old, the maximum daily dose by weight is 20 mg/kg.

Is it better to take naproxen at night or morning? ›

According to a new study, published in the journal Scientific Reports, using NSAIDs during the daytime might be preferable to taking them at night (such as before bed).

Can you take vitamin D with naproxen? ›

Interactions between your drugs

No interactions were found between naproxen and Vitamin D3.

Can I have coffee with naproxen? ›

Can you take naproxen with coffee? Avoid taking another NSAID. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. Do not consume coffee, tea, cola, energy drinks, or any other sources of caffeine while taking this medication.

How many hours does naproxen last for pain? ›

Naproxen (Aleve) and ibuprofen both belong to a class of medications called non-steroidal anti-inflammatory drugs (NSAIDs). They are similar and usually used for mild to moderate pain. However, naproxen (Aleve) lasts for 8 to 12 hours, while ibuprofen only lasts for 4 to 6 hours.

What is the safest pain reliever to take with high blood pressure? ›

Acetaminophen (Tylenol) is often the pain reliever of choice for people with high blood pressure (hypertension) because most other options are types of nonsteroidal anti-inflammatory drugs like ibuprofen (Motrin, Advil) or naproxen (Naprosyn, Aleve), which can raise blood pressure.

Does naproxen affect heart rate? ›

Prescribing NSAIDs (everything from ibuprofen and naproxen to celecoxib) seems linked to increased risk for a common heart rhythm problem known as atrial fibrillation (AF), reported researchers in Taiwan. The number of persons with AF is on the rise; it now affects more than 6 percent of the elderly population.

Why can't you take anti inflammatories with blood pressure medication? ›

Nonsteroidal anti-inflammatory drugs (NSAIDs) can induce an increase in blood pressure (BP) and may potentially reduce the efficacy of several antihypertensive drugs.

Can naproxen affect your brain? ›

We found brain activation reductions under naproxen compared to no treatment in different cortical and subcortical core pain processing regions (p ≤ 0.001). Compared to placebo, naproxen triggered an attenuation of amygdala activation (p = 0.001).

How does naproxen affect the nervous system? ›

Case reports have identified numerous neurologic sequelae including ataxia, vertigo, dizziness, recurrent falls, nystagmus, headache, encephalopathy, and disorientation. Seizures have also been reported, mostly after overdose ingestions, but even therapeutic doses have occasionally been associated with seizures.

Can naproxen cause bladder problems? ›

Bladder problems: This medication may cause bladder pain, painful or difficult urination, or increased frequency of urination. If these symptoms occur without an explanation (e.g., infection), stop taking this medication and contact your doctor.

What should be monitored when taking naproxen? ›

Nonsteroidal anti-inflammatory drugs should be used cautiously in those patients at high risk for complications. Strategies can be used to limit toxicity. Patients taking these drugs long term should be monitored periodically for signs of blood loss, renal dysfunction, and hepatic dysfunction.

Can naproxen damage your kidneys? ›

Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis.

How do I get naproxen out of my system? ›

You can remove drugs from your system by staying hydrated, exercising, eating a healthy diet, and avoiding alcohol or caffeine.

What time of day should naproxen be taken? ›

It's also available as a liquid. Always take naproxen with or just after a meal so it does not affect your stomach.

Can I suddenly stop taking naproxen? ›

If you stop taking the drug suddenly or don't take it at all: You may experience more pain and inflammation caused by your condition. If you miss doses or don't take the drug on schedule: Your medication may not work as well or may stop working completely.

How long does it take to flush naproxen out of your system? ›

How is Naproxen Metabolized? The drug is metabolized by the liver, and its by-products are eliminated through the urine. On average, the medicine and its metabolites are completely cleared from the body for 2.5 days, but it may take as long as 4 to 5 days for full elimination.

What happens if you take naproxen daily? ›

So using naproxen for long periods of time can raise the risk of serious side effects, such as kidney damage, gastrointestinal bleeding, and heart attacks. And the longer you take it, the higher your risk of serious side effects becomes.

Can naproxen cause heart palpitations? ›

Some prescription pain relievers such as ibuprofen and naproxen may be linked to irregular heartbeat, a condition that can increase your risk of stroke and heart failure.

Which is worse for blood pressure ibuprofen or naproxen? ›

Since ibuprofen and naproxen are both NSAIDs, they have the same side effects. However, the risk of heart and blood pressure-related side effects is greater with ibuprofen.

Does naproxen affect the liver? ›

Nonprescription pain relievers such as acetaminophen (Tylenol, others), aspirin, ibuprofen (Advil, Motrin IB, others) and naproxen (Aleve, others) can damage your liver, especially if taken frequently or combined with alcohol.

Does drinking more water raise or lower blood pressure? ›

Still, you can make lifestyle changes to bring your blood pressure down. Something as simple as keeping yourself hydrated by drinking six to eight glasses of water every day improves blood pressure. Water makes up 73% of the human heart,¹ so no other liquid is better at controlling blood pressure.

How many days in a row should you take naproxen? ›

For how many days can I take Aleve? Do not take for more than 10 consecutive days for pain or 3 days for fever unless directed by a doctor.

Can I take naproxen every day for arthritis? ›

It is perfectly safe to take Naproxen every day (and multiple times a day) for short periods of time as short-term pain relief. At The Independent Pharmacy, we offer Naproxen in two doses: Naproxen 250mg tablets and Naproxen 500mg tablets.

What vitamin should not be taken together? ›

Vitamin C and B12

It's not advised to take vitamin C and vitamin B-12 at the same time, says Litt. That's because high doses of vitamin C can reduce the amount of vitamin B-12 that's absorbed and metabolized by the body, she says. Be sure to take vitamin C at least two hours after vitamin B-12.

What should you not mix with vitamin D? ›

Phenobarbital, phenytoin, and other anticonvulsant medications -- These medications may accelerate the body's use of vitamin D. Mineral oil -- Mineral oil also interferes with absorption. In addition, Vitamin D may enhance the effects of doxorubicin , a medicine used to treat a variety of cancers.

Is there any medication you should not take vitamin D with? ›

Diltiazem (Cardizem, Tiazac, others).

Avoid taking high doses of vitamin D with this blood pressure drug. High doses of vitamin D can cause hypercalcemia, which might reduce the drug's effectiveness.

Is naproxen harmful to the body? ›

NSAIDs such as naproxen may cause ulcers, bleeding, or holes in the esophagus (tube between the mouth and stomach), stomach, or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death.

What medication can you not drink coffee with? ›

Danger: Don't mix these meds with coffee
  • Ephedrine. Ephedrine is a stimulant that speeds up the nervous system. ...
  • Antidiabetic drugs. ...
  • Theophylline. ...
  • Phenothiazines. ...
  • Anticoagulant drugs. ...
  • Tricyclic antidepressants. ...
  • Asthma medications. ...
  • Contraceptive drugs.
23 Jun 2021

Is naproxen a painkiller or muscle relaxer? ›

Naproxen is not technically a muscle relaxer; it is a pain medication and also helps with inflammation.

When should naproxen be avoided? ›

NSAIDs are generally not recommended for people with kidney disease, heart failure, or cirrhosis, or for people who take diuretics. Some patients who are allergic to aspirin may be able to take selective NSAIDs safely, although this should be discussed in advance with a health care provider.

What medications should not be taken with NSAIDs? ›

When combined with blood-thinning medicines (such as warfarin) NSAIDs increase the risk of bleeding. NSAIDs can cause kidney failure when they are combined with ACE inhibitors (medicines used to treat heart problems and high blood pressure) and diuretics (medicines to remove excess fluid).

What can you pair with naproxen? ›

If you need additional pain relief, you can combine aspirin, naproxen, or ibuprofen with acetaminophen. However, do not take aspirin, naproxen, or ibuprofen within 8-12 hours of each other. Also, watch out for pain medications that might be included in combination products such as those used for cough and cold.

Does naproxen interfere with heart medication? ›

2. NSAID pain relievers, such as naproxen and ibuprofen. If you have atrial fibrillation (irregular heartbeat) and are on blood thinners to lower your risk of blood clots and stroke, beware of nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs include common pain relievers naproxen (Aleve®) and ibuprofen (Advil®).

Why should you stop taking naproxen? ›

Naproxen may increase the risk of heart disease.

Using naproxen in the long term or at high doses increases your risk. People with heart disease or risk factors for heart disease, such as high blood pressure, also have higher risk. Naproxen shouldn't be used for pain before or after heart bypass surgery.

What organs are damaged mostly by taking NSAIDs? ›

Other than gastrointestinal and cardiovascular complications, habitual use of NSAIDs are also associated with nephrotoxicity and eventual renal failure [25] together with other transient effects on water and electrolyte balance.

What is the very best anti-inflammatory? ›

What is the strongest anti-inflammatory medication? Research shows diclofenac is the strongest and most effective non-steroidal anti-inflammatory medicine available. 10 Diclofenec is sold under the prescription brand names Cambia, Cataflam, Zipsor, and Zorvolex.

What happens if you drink coffee with naproxen? ›

These medications are used to slow blood clotting and include aspirin, clopidogrel (Plavix), ibuprofen (Advil, Motrin, and others), naproxen (Anaprox, Naprosyn, and others), enoxaparin (Lovenox), and more. Health experts advise caution when combining them with coffee, which can also slow blood clotting.

Is naproxen safer for the heart? ›

Naproxen (Aleve) has the lowest risk of heart attacks, making it a safer option, although you should always discuss using NSAIDs with your provider first.

Does naproxen make your heart race? ›

Common painkillers linked to increased heart risks, new study finds. Some prescription pain relievers such as ibuprofen and naproxen may be linked to irregular heartbeat, a condition that can increase your risk of stroke and heart failure.

Can naproxen cause heart failure? ›

There is a growing body of evidence that NSAIDs may increase the risk of harmful cardiovascular events including heart attack, stroke, heart failure, and atrial fibrillation. Given the widespread use of NSAIDs, these findings have generated significant concern among patients and healthcare providers.

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